retatrutide mechanism triple agonist gip glp-1 glucagon receptor Structural insights into the agonism at GLP-1R, GIPR and GCGR manifested by Retatrutide: How the Triple Agonist

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Compound AOD-9604 Class Synthetic hGH C-terminal fragment (16 aa) FDA Status Not FDA-approved Evidence Strength Phase 2b primary endpoint missed

Glu 128 interacts with a positively charged residue in both GLP-1 and exendin-4, which may explain why the E128A substitution did not have a differential effect on the binding affinity of GLP-1 and exendin-4

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Szabados, L